Kevin W. McCool
3rd year graduate student
Molecular & Cellular Pharmacology
5th year of MSTP

EDUCATION

• B.A. 2005, University of Wisconsin-Madison
  Molecular Biology

RESEARCH EXPERIENCE

• University of Wisconsin-Madison, 6/2003-2005
  Advisor - Michael Fritsch, PhD
  Project - Establishing RNA interference as a tool for functional analysis of the role of SRC-3/AIB1/ACTR in breast cancer cells studying global changes in histone deacetylase protein expression in differentiating mouse embryonic stem cells. Independent project investigating regulation of two sex steroid hormone receptors during differentiation in murine embryonic stem cells.

PUBLICATIONS

• McCool KW, Xu X, Singer DB, Murdoch FE, Fritsch MK: The role of histone acetylation in regulating early gene expression patterns during early embryonic stem cell differentiation. J Biol Chem 282(9):6696-6706, 2007. PMID: 17204470
• Lee ER, McCool KW, Murdoch FE, Fritsch MK. Dynamic changes in histone H3 phosphoacetylation during early embryonic stem cell differentiation are directly mediated by mitogen- and stress-activated protein kinase 1 via activation of mitogen activated protein kinase pathways. J Biol Chem. 281:21162-21172, 2006.

PRESENTATIONS

• "Regulation of Sex Steroid Hormone Receptors During Differentiation in Murine Embryonic Stem Cells." Pfizer Summer Undergraduate Research Fellows Symposium, 2004.